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Author Topic: GDF11 protein dalam darah org muda menjadi factor anti aging (serum awet muda)  (Read 1463 times)

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Offline kullatiro

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Young Blood May Hold Key to Reversing Aging

Two teams of scientists published studies on Sunday showing that blood from young
mice reverses aging in old mice, rejuvenating their muscles and brains. As ghoulish
as the research may sound, experts said that it could lead to treatments for disorders
like Alzheimer’s disease and heart disease.

“I am extremely excited,” said Rudolph Tanzi, a professor of neurology at Harvard
Medical School, who was not involved in the research. “These findings could be a
game changer.”

The research builds on centuries of speculation that the blood of young people
contains substances that might rejuvenate older adults.

In the 1950s, Clive M. McCay of Cornell University and his colleagues tested the
notion by delivering the blood of young rats into old ones. To do so, they joined rats
in pairs by stitching together the skin on their flanks. After this procedure, called
parabiosis , blood vessels grew and joined the rats’ circulatory systems. The blood
from the young rat flowed into the old one, and vice versa.

Later, Dr. McCay and his colleagues performed necropsies and found that the
cartilage of the old rats looked more youthful than it would have otherwise. But the
scientists could not say how the transformations happened. There was not enough
known at the time about how the body rejuvenates itself.

It later became clear that stem cells are essential for keeping tissues vital. When
tissues are damaged, stem cells move in and produce new cells to replace the dying
ones. As people get older, their stem cells gradually falter.
In the early 2000s, scientists realized that stem cells were not dying off in aging
tissues.

“There were plenty of stem cells there,” recalled Thomas A. Rando , a professor of
neurology at Stanford University School of Medicine. “They just don’t get the right
signals.”

Dr. Rando and his colleagues wondered what signals the old stem cells would receive
if they were bathed in young blood. To find out, they revived Dr. McCay’s
experiments.

The scientists joined old and young mice for five weeks and then examined them.
The muscles of the old mice had healed about as quickly as those of the young mice,
the scientists reported in 2005 . In addition, the old mice had grown new liver cells at
a youthful rate.

The young mice, on the other hand, had effectively grown prematurely old. Their
muscles had healed more slowly, and their stem cells had not turned into new cells
as quickly as they had before the procedure.

The experiment indicated that there were compounds in the blood of the young mice
that could awaken old stem cells and rejuvenate aging tissue. Likewise, the blood of
the old mice had compounds that dampened the resilience of the young mice.
Amy J. Wagers , a member of Dr. Rando’s team, continued to study the blood of
young mice after she moved in 2004 to Harvard, where she is an associate professor.
Last year, she and her colleagues demonstrated that it could rejuvenate the hearts of
old mice.

To pinpoint the molecules responsible for the change, Dr. Wagers and her colleagues
screened the animals’ blood and found that a protein called GDF11 was abundant in
young mice and scarce in old ones. To see if GDF11 was crucial to the parabiosis
effect, the scientists produced a supply of the protein and injected it into old mice.
Even on its own, GDF11 rejuvenated their hearts .

Dr. Wagers and her colleagues wondered whether GDF11 was responsible for the
rejuvenation of other tissues. In the current issue of the journal Science, they report
an experiment on skeletal muscle in mice. They found that GDF11 revived stem cells
in old muscles , making old mice stronger and increasing their endurance.


http://mobile.nytimes.com/2014/05/05/science/young-blood-may-hold-key-to-reversing-aging.html?referrer=&_r=0

mitos drakula awet muda karena minum darah orang muda ternyata benar yah, lupa ada sejarah tentang kaisar wanita yang mandi darah orang orang berusia muda agar tetap awet muda.
« Last Edit: 22 December 2014, 07:32:23 AM by kullatiro »